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Thus, an interesting question concerns how altered lamin A proteins cause disruption of the normal organization of the nuclear genome and how such spatial disruptions cause deficiencies in DNA repair processes even though DNA repair or metabolism genes are not defective.
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Despite the firm's best intentions and work to minimize the impact of the spatial disruption caused by the relocation, the racial segregation of the area's housing market hampered minorities' adjustments to the relocation.
Together, these observations support the view that genome-wide instability resolving as a cell line/culture-specific spatial disruption of the nuclear scaffold/matrix presents as differences in their locations when various studies are compared.
Resolution of these possibilities will require identification of protein targets of srn-mediated fucosylation and exploration of their role in CNS synaptic connectivity, and/or analyses of mutants with more precise spatial and temporal disruption of Notch-Delta signaling than are currently available.
This causes spatial and functional disruption of interphase G1 chromatin and may lead to formation of bi-nucleate cells [ 35, 36].
Further characterization of these animals, as well as the generation of new models, e.g. bearing spatial and/or temporal disruption of IRPs, or engineered for tissue-specific expression of constitutive mutants, is expected to improve our understanding on the function of the IRE IRP network in health and disease.
Previous work suggests that the activation of N-methyl-d-aspartate (NMDA) receptors specifically containing GluN2B subunits may underlie the disruptions in spatial memory retrieval caused by acute stress (Wong et al., 2007 PNAS 104:1047104
This indicates that pigs isolated in a novel environment are susceptible to mild disruptions of spatial memory.
Given our previous findings of mPFC DA hypofunction following adolescent social defeat, we hypothesized that previously defeated rats would demonstrate disruptions in spatial working memory performance in adulthood.
Wang and Ouyang (2013) presented a model for optimizing service facility location design under spatial competition and facility disruption risks.
This paper presents game-theoretical models based on a continuous approximation (CA) scheme to optimize service facility location design under spatial competition and facility disruption risks.
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