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The chaotic spatial disarray due to extracellular matrix expansion disrupts cardiomyocytes interaction and causes arrhythmia.
We hypothesized that disordered nanopeptide scaffolds can mimic the chaotic spatial disarray related to cardiac fibrosis and have arrhythmogenic effects on cardiomyocytes.
However, the spatial disarray of collagen fibers underlying atrial fibrosis is not fully elucidated.
Atrial fibrosis creates a vulnerable tissue for atrial fibrillation (AF), but the spatial disarray of collagen fibers underlying atrial fibrosis is not fully elucidated.
The aims are: 1) observe collagen fibers in atrial tissues by harmonics optical microscopy; 2) quantify the spatial disarray of collagen fibers by mathematical methods; and 3) compare differences of collagen alignment and serum fibrosis markers in patients with and in those without AF.
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For spatial relations?
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