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Because we were interested in the concordance of spatial abnormality patterns and corresponding standard normal deviate relative to controls, SPM-derived mean z-scores were extracted from multiple significant clusters (thresholded at p < 0.001, uncorrected for multiple comparisons [cluster size ≥ 10]).
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Attention difficulties, visual spatial abnormalities, and impaired executive function are also common.
The main finding of this study was that similar spatial abnormalities in glucose metabolism and perfusion were seen in AD and FTD patients compared with cognitively normal subjects in areas consistent with disease models.
"This surgeon had visual-spatial abnormalities, could not do fine motor movements, could not retain information, and his verbal I.Q. was much lower than you'd expect".
Because of this spatial alignment, abnormalities in developmental processes or in clearance of damaged, particularly insoluble proteins, are often observed in vivo as localized opacities or cataracts.
The SPARE-AD (Spatial Pattern of Abnormality for Recognition of Early Alzheimer's disease) is an index that captures brain atrophy related to AD [ 27, 28].
The aim of the present study was to quantify the spatial and spectral abnormalities in brain activity at a resting state with MEG and to assess its relationship with clinical characteristics.
For the problem of localizing the spatial location of an abnormality on the scalp, it requires the simultaneous analysis of the multiple EEG signals which are provided from the different electrodes placed on the scalp.
We considered whether the abnormality of spatial working memory could be attributed to deficits in memory acquisition that do not depend on the hippocampus.
Our data are more consistent with that of Bernhardt et al. in terms of the spatial topology of thalamic abnormality, but we delineate the thalamic region preferentially connecting to the temporal lobe, and provide combined measures of region-specific thalamic pathology based on a multisequence MRI approach.
In particular, we attempted to classify individual disorders by modelling neuroanatomical abnormalities as spheres centred on the peak coordinates reported by the individual studies, without taking the heterogeneous spatial extent of these abnormalities into account.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com