Sentence examples for sparse pharmacokinetic from inspiring English sources
A mixture of rich and sparse pharmacokinetic sampling was performed in a subset of patients.
Simultaneous modelling of dense and sparse pharmacokinetic data is possible with a population approach.
Several anabolic steroids may produce clinically significant false positives on the testosterone assay, although interpretation is limited by sparse pharmacokinetic data for some of these drugs.
However, this approach is subject to biased estimates, especially with sparse pharmacokinetic sampling, where the individual predictions are susceptible to the problems of shrinkage.
The final model was internally evaluated using stochastic simulations and bootstrap and externally evaluated using sparse pharmacokinetic data from 311 subjects treated in a long term safety study of LCIG.
Additional studies are needed to assess in more detail the mode of action, metabolism, and clinical efficacy of tramadol in the dog during chronic oral dosing, as only sparse pharmacokinetic data are available to date [ 22].
Even when the pharmacokinetic data are sparse and cannot be used to fully characterize the drug exposure profile, the inclusion of only predose concentrations could capture a significant part of the interindividual variability.
Moreover, there are a number of metabolites of potential toxicologic interest, such as chloral, dichloroacetic acid, and those derived from glutathione conjugation, for which reliable pharmacokinetic data is sparse because of analytical difficulties or low concentrations in systemic circulation.
Two datasets (sampling design A: dense; sampling design B: sparse) were simulated using a pharmacokinetic model that included a binary covariate effect and subsequently re-estimated using (1) the same model and (2) a model not including the covariate effect in NONMEM 7.2.
Pharmacokinetic data are still sparse for amodiaquine.
Data from patients with frequent sampling were analyzed non-compartmentally, whereas data from both patients with frequent and patients with sparse sampling were used for population pharmacokinetic analysis.
