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The sparse interaction and main effects of treatments were small and inconclusive.
Of note, because the coverage of the interactome is incomplete, many pathways have sparse interaction coverage, leading to fewer enriched gene sets detected by PIPA relative to HGA.
The NetGenerator approach aims to identify a set of model parameters which is optimal with respect to the given input data and the presumption of a sparse interaction matrix.
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We focus on problems in which the interaction between the agents is sparse and contribute a new decision-theoretic model for decentralized sparse-interaction multiagent systems, Dec-SIMDPs, that explicitly distinguishes the situations in which the agents in the team must coordinate from those in which they can act independently.
Once three such subnetworks are computed, their nodes are coupled by sparse, weak interactions.
Treating proteins as nodes and interactions between proteins as edges, we obtain a sparse protein-protein interaction network.
We did not attempt to extend the occupational exposure analysis to selected agents because such data were too sparse for an interaction analysis and were more likely to be biased because of subject recall.
Habitats that were structurally dense also supported the most complex trophic interactions among predators and prey, whereas structurally sparse habitats had low interaction diversity and interaction evenness, with most energy flowing along few trophic pathways.
There was no evidence for effect modification by age, although data were too sparse to estimate interactions with gender.
To achieve a sparse pattern of interactions, such methods usually employ sparsity-inducing priors in a Bayesian setting or regularization penalties in an optimization-based scenario.
The gene regulatory network (GRN) abstraction aims at explaining the joint variability in the expression levels of a group of genes through a sparse pattern of interactions; elucidating the topology of GRNs can provide important insights in the fundamental biology of the system and suggest possible intervention points in biomedical applications.
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