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Like TV, the HOTV approach promotes solutions with sparse boundary regions.
In addition to reducing unwanted noise, TV regularization encourages a piecewise constant solution with sparse boundary regions.
In Fig. 1, it is shown that most true DEGs are outliers located in the sparse boundary region in the (d, e) space.
A density based pruning algorithm (DB Pruning) is developed to screen out potential differentially expressed genes usually located in the sparse boundary region.
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She deserved to let her already sparse boundaries lend her even more brashness and more relevance.
It converges to a partition of highly-connected regions (the clusters) separated by sparse boundaries.
Third, many complexes are small (composed of two or three distinct proteins), so that traditional topological markers such as density or sparse boundaries are ineffective.
The sparse outer boundaries of these regions are less highly conserved and are under positive selection.
With the hindsight provided by recent surveys of spatial genomic domains based on chromatin conformation capture [ 6], we can identify the signature of housekeeping genes localised to nucleosome-sparse domain boundaries by our inability to predict their expression using HM ChIP-seq data.
However, most of these methods make an assumption that a sparse set of boundary points or interest points have been extracted beforehand.
Because dinosaur fossils in rocks laid down just before the K-T boundary are sparse, it's been tough to know whether these beasts were thriving right up until the asteroid impact.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com