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Ten years ago, they began a project to track the age of neurons in the human brain using an unusual tool: spare molecules left over from Cold War-era nuclear bomb tests.
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In the recent decades, with the deepening understanding of life and the progress of molecular biology, researchers spare no effort to design molecules targeting one or two key enzymes and receptors related to corresponding diseases.
NK cells efficiently lyse target cells lacking expression of MHC class I molecules, but usually spare cells expressing sufficient levels of self-MHC.
This ensures that tumor cells become coated with the RIT molecules while normal cells are spared from the DNA-blasting radiation.
To do so, say the researchers, they will need to develop highly specific targeting molecules for each disease to ensure that healthy blood cells are spared.
Spare tire.
Spare socks.
Fat, spare.
"Spare me.
Spare chromosomes mean spare genes.
Since there are lots of possible molecules, and each has lots of possible shapes, the analysis is particularly suited to this kind of distributed computing approach, in which the spare processing power of thousands or millions of computers is used.
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CEO of Professional Science Editing for Scientists @ prosciediting.com