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We gave diazinon (DZN) to newborn rats on postnatal days 1 4, using doses (0.5 or 2 mg/kg) spanning the threshold for barely detectable cholinesterase inhibition.
For each agent, we evaluated doses spanning the threshold for the emergence of systemic toxicity as defined by growth impairment and decreased viability.
We contrasted neuritic outgrowth and cholinergic synaptic development in neonatal rats given different organophosphates (chlorpyrifos, diazinon, parathion) at doses spanning the threshold for impaired growth and viability.
We gave parathion to neonatal rats [postnatal days (PNDs) 1 4], at daily doses of 0.1 or 0.2 mg/kg, spanning the threshold for barely detectable cholinesterase inhibition and systemic effects.
In the present study, we evaluated the immediate effects of neonatal treatment with doses of diazinon and parathion below the maximum tolerated dose (Slotkin et al. 2006) and spanning the threshold for barely detectable cholinesterase inhibition.
We then administered CPF or DZN to neonatal rats on postnatal days 1 4 using daily doses spanning the threshold for AChE inhibition (0 20%); we then evaluated AChE gene expression in forebrain and brainstem on post-natal day 5.
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The doses we chose for daily treatment of neonatal rats with diazinon or parathion on PND1 4 spanned the threshold for significant inhibition of cholinesterase in the brainstem and forebrain.
The population parameters for a wide range of microorganisms can be seen to span the threshold that separates recombining and clonal populations regardless of the distance factor (fig. 4).
The mean HbA1c level obtained from Micromat II was significantly lower than that yielded from the three types of laboratory analysis, and this difference spanned the treatment threshold level currently recommended by the American Diabetes Association ADAA) [ 12].
An FDR-adjusted P-value (Padjusted) sensitivity plot was generated by plotting the number of genes altered at every Padjusted value cut-off, with P-value thresholds spanning the range from Padjusted = 1 × 10−6 to Padjusted = 0.5.
For all datasets it is possible to identify a peak that stands out in comparison with the others by spanning the largest range of similarity threshold t.
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