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Our fine-mapping effort revealed evidence that one height locus at chromosome 17q23.2 appears to consist of two associations spanning multiple regions of linkage disequilibrium in our sample of African American individuals.
These results suggest the presence of two associations within one region of linkage disequilibrium in the CEU and CHB samples but spanning multiple regions of linkage disequilibrium in our African American sample.
A read spanning multiple regions, e.g. multiple exons, is denoted by multiple alignment blocks that are separated by a comma.
In addition to CNV calls at the region (exon) level, CONTRA offers a function to predict large CNVs spanning multiple regions.
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If a gene spans multiple regions of linkage disequilibrium, then the latter choice is preferable because it requires less genotyping and induces a smaller statistical testing burden.
The mutations found in patients span multiple regions of the WDR62 protein and include missense mutations as well as small deletions resulting in a frameshift followed by a stop codon.
In tinnitus, we suggest that an area of auditory cortex spanning multiple tonotopic regions is chronically stimulated, and these regions are subject to relatively balanced lateral inhibition.
For detecting large CNVs spanning multiple target regions, we first perform circular binary segmentation (Olshen et al., 2004) on RLRs, using different parameters to achieve different resolutions of segmentation.
Finally, the chapter analyzes the peculiarities of traffic engineering on networks that span multiple regions and administrative domains.
Quantitative assessment of integrated, multimedia models that simulate hundreds of sites, spanning multiple geographical and ecological regions, will ultimately require a comparative approach using several techniques, coupled with sufficient computational power.
The provisioning of quality of service guarantees over a region spanning multiple administrative domains is nowadays one of the most basic and crucial issues.
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