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Consistent with a role for dopamine signaling in life span regulation, the genes Ddc and Catsup regulate the dopamine biosynthetic pathway, and previous studies show that natural variation in these genes affects both courtship behavior and life span [ 34, 35].
In this context, mammalian SIRT proteins that regulate histone deacetylation at chromatin can contribute to aging and life span regulation.
Shen, J. & Tower, J. Programmed cell death and apoptosis in aging and life span regulation.
P. Fabrizio, S. D. Pletcher, N. Minois, J. W. Vaupel, V. D. Longo, Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae.
Importantly, in higher eukaryotes pathways that appear to share a common evolutionary origin with the Sch9 and TOR pathways are also implicated in life span regulation.
Studies in a variety of species have shown that the IGF signaling pathway plays a fundamental role in regulating wide range of physiological events from embryonic development and growth to life span regulation [12], [13].
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Oxidative stress has a prominent role in life-span regulation of living organisms.
While these processes are known to be involved in aging in fruit flies, nematode worms, and yeast, TOR's precise role in life-span regulation is still unclear.
The protein p66Shc, which has been implicated in life-span regulation and aging-related diseases, is a central player in stress-induced apoptosis and the associated ROS burst.
The insect Methuselah receptors are one such example that have become the subject of great investigation, attributable to their role in life-span regulation and stress resistance [ 66].
One of the proteins phosphorylated by JNK is p66Shc [ 9], an adaptor protein responsible for life-span regulation and cellular sensitivity to hydrogen peroxide and other cytotoxins.
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