Sentence examples for span in the context of from inspiring English sources

How DAs and DAF-12 influence life span in the context of reduced DAF-2/InsR signaling is poorly understood.

The daf-9 missense allele rh50 has distinct effects on life span in the context of specific daf-2 mutant alleles.

In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription factor DAF-16 extend life span in the context of reduced DAF-2 insulin-like growth factor receptor (IGFR) signaling.

In daf-36 (null) animals, which lack both Δ- and Δ-DA (Wollam et al. 2011), DAF-12 extends life span in the context of daf-2 RNAi but shortens life span in the contexts of the Class 1 daf-2 (e1368 ) allele and germline ablation.

To test whether E. coli strain differences influence the effect of daf-12 (null) on life span in the context of reduced DAF-2/InsR activity, we performed life span assays with daf-2 (e1368 ) and daf-2 (e1370 ) mutant animals grown on E. coli HT115 (expressing empty vector control RNAi) as the food source.

Here we specifically investigated the roles of liganded and unliganded DAF-12 in life span control in the context of reduced DAF-2/InsR signaling.

A loss-of-function mutation in the conserved gene gst-20, which is induced by DAF-16A, reduced life span extension in the context of daf-2 /IGFR RNAi without influencing longevity in animals subjected to control RNAi.

Taken together, these results suggest that DAF-12 is required for life span extension in the context of RNAi knock-down of daf-2, but is largely dispensable for longevity in the context of Class I daf-2 (e1368 ) and Class II daf-2 (e1370 ) mutants (see comparison of replicate experiments in Figure 2D).

Given that the main RNAi library used in the C. elegans field was constructed using E. coli HT115 (Kamath et al. 2003), which is distinct from the standard OP50 strain used in C. elegans studies, our findings underscore the importance of verifying RNAi-based life span assays in the context of E. coli OP50.

In vivo, critically short telomeres result in stem cell dysfunction, premature loss of tissue regeneration, and reduced life span, as shown in the context of telomerase-deficient mice (Blasco et al, 1997; Herrera et al, 1999; Rudolph et al, 1999; Gonzalez-Suarez et al, 2000; Collins and Mitchell, 2002; Blasco, 2005; Garcia-Cao et al, 2006).

From now on, within the process of duty revision negotiations, spans must be looked at in the context of an enabler rather than a fixed amount of time to be aimed at".