Exact(49)
C. elegans is a relevant model system for evaluating the efficacy of life span extending herbs due to the high conservation of biochemical pathways from worms to humans, and because of the similarity of many aspects of aging shared by nematodes and humans.
The life span extending effects of DN-Dmp53 are furthermore smaller than the life span extending effects of CR.
These data indicate that Dmp53 and dSir2 share a similar life span extending mechanism.
We propose a model for the life span extending effects of CR in flies.
Thus, our studies confirm a life span extending effect of reduced Indy/CeNAC2 expression in C.elegans.
AMPK/aak2 mediates the life span extending effect of glucose restriction in C. elegans [ 20].
Similar(11)
Although translation of life span extension from worm to humans is unknown, substantial experimental evidence suggest that life-span extending drugs are extremely useful in treatment of age-related diseases such as cancer and neurodegenerative diseases [22] [24].
As described earlier [ 26], overexpression of wtSNEV had a strong life-span extending effect.
In any case, the life-span extending and DNA repair functions of SNEV do partially depend on phosphor-rylation at S149, most probably in dependence of ATM.
All the life-span-extending herbs (SQDB, CIN and GS) also attenuated levels of H2O2 and enhanced small heat shock protein expression.
The intersection also contained two aquaporins, both up-regulated in all health span-extending interventions we studied.
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