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The UPSK seems to act as an important, though nonspecific, spacer element ensuring proper presentation of a functional TLS.
Cationic liposomes were formulated with and without the targeting ligand folate conjugated to distearoylphosphatidyl ethanolamine polyethylene glycol 2000 DSPE-PEG20000), the novel cytofectin 3β[N N1,N1-dimethlaminopropylsuccinamidoethane -carbamoyl]cholesterol (SGO4), which coN N1,N1-dimethlaminopropylsuccinamidoethane -carbamoyl]cholesteroloylphosphatidylethaN N1,N1-dimethlaminopropylsuccinamidoethane -carbamoyl]cholesterol
EIT used multilayer coated reflective mirrors that were coated with alternate layers of a light "spacer" element (such as silicon), and a heavy "scatterer" element (such as molybdenum).
In the case of 5' replacement, the spacer element can be removed without decreasing efficacy of trans-splicing constructs [15].
Next, we sought to extend the ITR2 spacer element to function as an extended RBE (Fig. 4C).
This panel of mutant ITR5s demonstrates the requirement for a three nt spacer element for Rep2 function.
Similar(47)
Most notably, the insertion of flexible oligo ethylene oxide) spacer elements between neighboring binaphthylene and azobenzene main-chain units had a pronounced damping effect on the photo-dynamic behavior exhibited by these chiral systems.
Rep5 displayed greater flexibility toward spacer elements of differing lengths.
The genetic Device for such a system is composed of three categories of protein domains: passenger domains, displayer domains, and structural spacer elements.
The spatial arrangement of the two ABDs along with the length and flexibility of the spacer elements determines whether a crosslinking protein induces bundling or network formation [1].
The same holds true for chimeric VLPs in which the Δpp65 moiety was exposed at the outer VLP surface by insertion into surface-exposed loops of Gag immediately N-terminal to position S182 and flanked by flexible spacer elements (Powilleit and Schmitt, unpublished).
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