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Lastly, the interstitial space of tumours is increased[ 4, 5].
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The resulting large, bulky PEG coating is believed to shield the liposomes, reducing their clearance via the RES, resulting in a long blood half-life and significant uptake within the interstitial space of subcutaneous tumours over 24 h [2,3,5,6].
The principle of DCE-MRI consists of serial measurements of signal intensity changes in both tumour tissue and a feeding artery after bolus injection of a paramagnetic CA. Depending on the physical properties of the CA and the leakiness of the microvessel wall, a fraction of the CA will reach the interstitial space of the tumour, where an increase in signal intensity over time will be observed.
Divergence and poor overlap of the AC and other lung tumours gene signatures suggests that our knowledge about nature and space dimensionality of tumour-associated genes (and potential biomarkers) is essentially incomplete [ 8- 12].
An immunohistochemical study showed that the inducible isoform of NO synthase (iNOS) was localized in monocyte-derived macrophages, which infiltrated interstitial spaces of solid tumour, but not in the tumour cells.
Most of the intrinsic malignancies of the masticator space are tumours of the mandible [5].
The course of 6 cycles CHOP-14/21 CHOP-14/2114 is shown in the phand space of effector and tumour cells for a typisal parameter combination.
The concentration of free (unbound) VEGF in the interstitial space of human breast tumour and muscle vastus lateralis have been measured using microdialysis.
The antibody binds to an antigen that is preferentially expressed on the surface or in the interstitial spaces of the tumour cells.
Extrinsic tumour involvement of the masticator space may result from direct extension of tumours from adjacent spaces or from perineural tumoral extension along the mandibular nerve or its branches.
Central hyperintensity (target appearance) has also been observed in the hepatocellular phase, believed to be related to contrast accumulation in the extracellular space of the fibrous stroma in these tumours.
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