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The space of mutations for ATP synthase inactivation is potentially large and, therefore, easily achieved.
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The original feature space of the mutations is the product of the number of positions times the 20 amino acids.
This study describes a relatively cost-effective way to explore combinatorial space of productive mutations within a single genome.
The infrequency of VEE emergence is probably determined by the infrequent, simultaneous occurrence in time and space of viral mutations that mediate host range changes, combined with ecologic and epidemiologic conditions that permit efficient amplification (1 ).
The 'mutation path' for each native sequence constitutes a single unique trajectory in the space of all possible mutations.
Modeling the origin of variation amounts to specifying a space of possible: how many mutations can arise per generation and what is the range of their fitness effects?
Directed evolution experiments, which probe the sequence space of a protein through mutations in search for an improved variant, frequently result in such inactive sequences.
The fuzzy-logic language is broadly applicable and could help define the space of tolerated and beneficial mutations in natural biomolecular systems and design artificial molecules that encode complex characteristics.
It will consequently act as a catalytic tool towards the re-definition of urban space, generating mutations on architectural morphology and typology.
"I consider the Allosphere as a portal, a vessel, a kind of high-fidelity threshold into the virtual and means of communing with this 'other of another kind.' In this context I found it appropriate to spill certain fundamental properties of organic growth and life into this other-space and allow for the kinds of mutations that might naturally emerge in a machine-language environment," he continues.
In a genotype space, the distance between two genotypes indicates the number of mutations that set those genotypes apart.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com