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The DSSTox Chemical Property database (DSSTox-ChemProp) was built as an add-on to DSSTox-Lists to capture measured or predicted property data associated with a particular source substance or list of chemicals (DTXRIDs).
The source substance powders were mixed in the same proportions and treated in cycles (the cycle time was 5 min) in the planetary-type ball mill (acceleration 50g, pressure on a substance particle 5 GPa).
In the read-across context, the source substance is a substance with available in vivo data, and the target substance is a similar substance without sufficient data.
The proposed active components of homeopathic remedies are nanoparticles of source substance in water-based colloidal solution, not bulk-form drugs.
We decided to use chemical categories for the case study, rather than using pairs of individual chemicals, because data available for any source substance in a category may be used to fill information gaps for substances with missing data.
Rey also noted that two remedies differed from one another in thermo luminescence patterns, but retained the "fingerprint" properties of the original source substance, even without the detectable presence of the bulk-form source material in solution.
Similar(53)
DTXRIDs are unique identifiers of source substances, mapping to a substance record from an external source list carrying all source-associated identifiers.
We agreed to choose categories for which toxicology studies are available for both target and source substances to facilitate the assessment of whether additional information actually is strengthening the read-across case.
The majority of drugs or their metabolites cross the placental barrier, 5 and metabolites may be more fetotoxic than their source substances, as was noted in the case of thalidomide-induced phocomelias.
Despite its open-source substance, it's hefty: Three meters tall, four meters in diameter.
Shaktism views the Devi as the source, essence and substance of virtually everything in creation, seen or unseen, including Shiva himself.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com