Having established that the biaryl scaffold appears to be the source of selectivity for the minor site in this series of compounds, the crystal structures and docking results were used to design a variety of compounds to explore the structure activity relationship (SAR) of various fragment lysine connectivities.
Comparisons with substrate bound X-ray structures of the dopamine transporter reveal a number of potential sources of selectivity, some of which may be 'artificial' including target based, species related, experimental design related, and ligand dependent examples including substrate versus inhibitor related features.
Since the locations of RSs (and main receiver) are assumed fixed during the whole duration of the communication, the movement of scatterers is expected to be the only source of time selectivity in the corresponding channel gains; as a result, the coherence time of the wireless channels for the second hop are expected to be much larger than the signaling delay.
It is evident from our comparison that TM7 displays the greatest sequence variability, which might be the source for interspecies selectivity.
Structure-guided synthesis informed the elaboration of these fragments to explore the source of ligand selectivity between the minor and major sites.
One potential source of differences in selectivity between K+ channels and HCN channels is the selectivity sequence of the P-loop, as previously suggested [1], [13], [14].
One possible source of this kinetic selectivity is that recognition of the fluorine substituent by FlK could force nucleophilic attack by Glu 50 to occur along a trajectory that is disfavored based on the Felkin Anh model for carbonyl addition.
There are two potential sources for a possible selectivity problem in our work: first, we only look at wage earners; hence, selectivity to employment could be a potential problem.
It is widely recognized that the success of the last approach depends mostly on the novelty of the microbial sources and on the selectivity of the screening strategy [ 19, 20].
The narrow frequency band of the source provides for greater energy selectivity of the upper state that is being populated.
