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Those traits under strong stabilizing selection may not be genetically canalized and the major source of selective pressure for canalization can result from the benefits gained by buffering the effects of environmental perturbations [ 4, 10].
In most cases, the source of selective pressure is unknown.
The glutamate at position 12 could be accurately and reversibly seen to be a source of selective bidentate ligation of Ca2+ in the simulations.
This situation may arise if, for example, Y represents the amino acid at a particular position in a sequence and X represents an environmental variable that we suspect may be a source of selective pressure on X, as in the case where we are looking for HLA alleles that exert pressure on specific HIV-1 molecules to select for escape mutations.
Similarly, a source of selective pressure must be envisaged to explain our findings.
Both groups of proteins are known to interact with viral proteins [ 28, 29], which may be a potential source of selective pressure.
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The resulting distributedness of the currently dominating form of intelligence might challenge the predicted cognitive architecture of the Global Brain, as it is likely to introduce additional powerful sources of selective pressures.
Both these sources of selective exposures would drag the investigated association towards that expected under the null hypothesis.
However hidden specificity caused by specific life history [ 30], and also possible conflicts of interest in VAM, can be taken on consideration as potential sources of selective pressure.
This results in a rather special situation, where both intra- as well as inter-specific niche differentiation between the two seal species could act as ecological sources of selective divergence.
Some researchers suggest that outbreaks of the bubonic plague, which killed 25 33% of Europeans about 650 years ago, are the most likely source of strong selective pressure for this mutation (Stephens et al. 1998).
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