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Another possible source of replication errors is continued DNA synthesis when the DNA is subjected to damage.
Dispersed repeats can generate inversions via recombination, whereas tandem-repeat-rich sequences may be a source of replication errors and DNA breakage.
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We now report that WRN is also important for preventing telomere loss induced by environmental sources of replication stress.
FA proteins appear to play a central role in the response to both endogenous and exogenous sources of replication obstacles.
However, we note that the implementation of MADGiC is flexible enough to accommodate other sources of replication timing data.
These data strongly suggest that the CD14+ macrophages that have recently entered the brain are the source of SIV replication during the earliest period of CNS infection and virus is not replicating to a significant level in microglia at this time.
TS catalyses the formation of thymidylate, a source of DNA replication, from dUMP (Danenberg, 1977).
One important source of post-replication repair involves the use of homologous recombination between sister chromatids [3].
Endogenous sources of DNA replication defects may drive the expression of FA symptoms.
Despite the numerous sources of heterogeneity, replication does not completely randomize or "reset" the cells, and the model allows for inter-generation memory.
In a framework of such scenarios, however, an essential source of monomers for replication would be the decay of other replicators.
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