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We hope that this library will provide an invaluable resource for the community to screen loss of function mutations for cellular phenotypes, and as a source of guide RNA designs for future studies.
The trickiest part of the model for pAgos in phage defense concerns the source of guide DNA or RNA.
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Thus, these investigations may be the best potential source of guiding diagnostic, therapeutic, prognostic, and economic medical decision making.
Rather than let those differences be a source of tension, guide the discussion so that the approaches complement each other.
However, the natural target RNA and the source of the guide DNA molecule(s) for this Argonaute remains to be determined and there is no experimental evidence of its physiological function.
Requesting information from former anesthesiology residents may be a source of information, guiding the specific types of PNBs that should be included in residency training.
Because gray mouse lemurs mark their home range with saliva, anal secretions, and urine, dispersers may use these odors as a source of information guiding their movements (Schilling 1979).
Although the source of RNA guides for such a system is unclear, an interesting possibility is that this version of Cascade might recognize alien DNA molecules and process nascent alien mRNA to generate RNA guides; such mechanism obviously would be analogous to the siRNA branch of the eukaryotic RNA interference systems [ 50].
Even considering such limitations of the current state-of-the-art, results generated from animal bone defect models provide an essential source of information to guide the design of BG scaffolds in future.
But so far nobody in the press has picked up the source of the supposed guide.
Kindness is your daily source of inspiration and guide to making a difference in fresh and exciting ways, no matter where you are.
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