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A number of different platforms are available for detection of CNVs, varying in their resolution (from ∼1 Mb for BAC arrays to a few kilobases for oligonucleotide and single nucleotide polymorphism arrays), coverage of the genome (targeted vs whole genome coverage) and source of comparator DNA.
Similar(59)
Inappropriate decisions regarding the choice of comparator could become a source of uncertainty (Bojke et al, 2009) and can bias the estimated added value of new treatments.
The results indicate that there is some degree of similarity regarding basic methodological elements such as selection of information sources, quality assessment of available evidence, choice of clinical endpoints, and choice of comparator(s).
We consider a class of comparator networks obtained from the omega permutation network by replacing each switch with a comparator exchanger of arbitrary direction.
Analyses were stratified by type of comparator.
The output of comparator is the desired PWM signal.
Data were limited by variability in the types of comparator groups, methodological limitations, and poor reporting of outcomes.
In contrast, the perturbation score we applied in the present study is independent of comparator data.
The search was not limited to one kind of comparator.
It is likely that exploration of these issues will require mixed methods research, combined with enhanced use of routinely collected data from public health and provider sources, and creative use of comparators for intervention sites [ 73, 74].
This chapter explores the key methodological elements of these registries in terms of patient enrolment, the source of exposure and outcome information, outcome definition and ascertainment and comparator groups and how these elements may influence the reported risk estimates.
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