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Platelets represent a major source of circulating MPs [52].
Subsequently, it was realized that K-cells are the predominant source of circulating GIP.
We feel that this report is hypothesis testing, and while observational in nature, it opens the door to what is possible with this, as yet, unexploited source of circulating mRNA.
The source of circulating sEpoR is also unknown.
The liver is the major source of circulating IGF-1.
Proteins highly enriched in culture media represent a potential source of circulating markers for ovarian cancer.
The fat tissue is a rich source of circulating bioactive factors that may act in a paracrine manner [45].
In some invertebrate species, such as Drosophila, brain neurons were the main source of circulating insulin [24], [25].
It is possible that adipose tissue is a major source of circulating nesfatin-1 in goldfish and that nesfatin-1 has a role in adipose metabolism.
We found that exposure to PM increases PAI-1 levels in the lung and in the white adipose tissue, the major source of circulating PAI-1 [30], [30].
Further investigation is warranted to test this speculation and to identify the location of the initial damage incurred in sepsis as the source of circulating actin.
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