However, they noted that few studies quantitatively compare total RNA and amplified RNA, that the true sources of amplification biases have not been thoroughly investigated, and that the degree to which "noise" affects the differences in these profiles has not been adequately assessed.
Many risk management approaches unfortunately impose far too much complexity on organizations, making them a source of risk amplification rather than a source of risk abatement.
While lacking definitive experimental evidence on the contribution of gap junctions to the regulation of burst firing in MDN, it is generally agreed that it induces similar firing between coupled cells, and thus constitutes a source of internal amplification, or recruitment within MDN populations (see Appendix S1).
Other sources of internal amplification may include the inactivation of A-type channels [55], NMDA receptor based excitation [56] and neuromodulator input [57]) (by analogy with thalamocortical population bursting, synchronized mainly via inhibitory thalamic reticular nucleus input [58]).
Traditional Asian wet markets provide major contact points for people and live animal mixing (because of lack of refrigeration, animals are usually alive when sold), making them important potential sources of viral amplification and infection (7).
However, the extent of magnitude- and source-distance-dependence of amplification ratios differs significantly.
We observed large tandem arrays of NBS genes near the telomere region of Pg1 (two 4-gene groups, four 5-gene groups and one 6-gene groups) followed by Pg4 (three 2-gene groups and two 4-gene groups) (Supplementary Fig. 11 and Supplementary Table 18), consistent with a biased distribution of these loci and suggesting that tandem duplication may be an important source of local gene amplification.
Also provided are the target gene name/annotation, template source for PCR and purpose of amplification.
Since each new copy will be a source of further new copies, amplification of transposons is necessarily exponential.
