Exact(5)
The clathrin lattice serves as an organizing scaffold for the proteins that carry out cargo sorting, membrane invagination, vesicle scission, and uncoating.
The model presented here will serve as a structural framework to explain many of the dynamic cellular processes occurring over several time scales, such as protein diffusion, association, and turnover, lipid raft sorting, membrane deformation, cytoskeletal-membrane interactions, and even effacement of the brush border by invading pathogens.
Hence, ESCRT-III filaments may have a dual role during MVB sorting: membrane budding/scission and cargo sequestration.
Recent work has uncovered a further deep evolutionary relationship between the multiple coats responsible for protein sorting, membrane deformation and vesicle budding.
These steps include cargo selection (sorting), membrane bending (budding), and membrane scission (fission) [29] and FAPP2 has the potential to participate in each of these events and possibly to coordinate them.
Similar(3)
HGS (also called HRS for Hepatocyte growth factor-regulated tyrosine kinase substrate) is an essential protein that belongs to multi-vesicular bodies (MVB /Lysosome complex, which is required to sort membrane proteins and direct them toward either degradation in lysosomes or recycling at the plasma membrane [ 20, 21].
In addition, a role for Ubp2 in properly sorting the membrane bound amino acid permease Gap1 directly from the Golgi to the MVB has also been reported [49].
Intermediate and late endosomes/MVBs sort membrane proteins into endosomal intraluminal vesicles to be degraded by vacuolar/lysosomal hydrolases upon fusion with vacuoles/lysosomes.
Related(1)
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