In spite of their utility and mathematical sophistication, these methods only provide approximate solutions to real-world problems where there is uncertainty and temporal change.
Recently, the accelerated pace and sophistication of methods for structural characterization of proteins has allowed high-resolution studies of increasingly complex assemblies and conformational changes.
The sophistication of methods used is influenced by three factors.
While calculating the costs of DEXA, CT, and MRI solely by the actual amount of time spent scanning makes these techniques comparable, the total costs remain significantly different because of the time and sophistication of methods needed to analyze the acquired data (Table 1).
Actually, these in silico predictions have not raised a lot of orphan cases despite the sophistication of the methods and their relative independence from classical sequence based methods.
Compared with the wealth and sophistication of imaging methods available for patients with MM, the sole reliance here on one method, FDG-PET, is a reminder that preclinical imaging of PCT in mice is in its infancy.
Of course, it is entirely right to demand that the Israeli government cease their subjugation of the Palestinians, but that does not mean that there should be an abandonment of sophistication over the methods employed in the quest for justice.
Apart from the greater sophistication of modern methods of heating and the use of resin (or oil for use on canvas), present-day technique is similar to that described by the 1st-century-ad Roman scholar Pliny the Elder.
And the sophistication of attack methods is only increasing and becoming more difficult to detect.
In recent years, we have noticed a marked increase in the number of rogue pharmacies, as well an increasing sophistication in their methods.
