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Several global approaches are routinely employed to predict function, including sophisticated sequence analysis, gene expression, protein interaction, and protein structure.
Moreover, it is illustrated that a sophisticated sequence design can further improve the achievable rate significantly compared to i.u.d.u.d
In the same period, developmental psychologists are making a growing use of video, with the use of sophisticated sequence analysis software, as well as software enabling for following gazes.
Additional assessments of siRNA specificity reveal that more sophisticated sequence comparison tools are also required to minimize potential off-target effects (Jackson et al., 2003; Semizarov et al., 2003).
Second, the emergence of more sophisticated sequence searching algorithms, such as profile-profile matching [2], improve the probability of finding a suitable search model, even in cases of very low similarity (<20% identity).
This appears to be the case even when using sophisticated sequence comparison methods like psi-blast.
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Over the preceding two decades, sophisticated sequencing techniques have been used to characterize the genetic drivers of adult melanoma.
Practices involved in the management of ash tree resources include highly sophisticated sequences, and reflect an intimate knowledge of the biology of these resources.
Sophisticated sequencing regimens designed to exploit different mechanisms of action have the potential to confer greater clinical benefit than the historical approach of selecting the agent with the next highest single-agent clinical activity upon disease progression.
To accommodate these regions of imperfect pairing in duplexes between the 3' end of a miRNA and its mRNA target site, sophisticated sequence-based methods may search for near-perfect WC complementarity in the seed region (miRNA positions 2 7, 2 8 or 1 7) [14], [14] then extend the search e.g. to the 3' end of the miRNA, rather than attempting to align the entire miRNA in a single operation.
More sophisticated sequence-based methods of measuring antigenic distances for influenza viruses have been explored by He and Deem in a series of papers involving, for example, identification of clusters of 2009 H1N1 strains, connected according to time-ordered single amino acid mutations and minimal nucleotide mutations [ 38].
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