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Hansen, R. S. et al. Sequencing newly replicated DNA reveals widespread plasticity in human replication timing.

Timing of firing at origins is approximated by the average replication timing of the peak loci.

Identification of replication timing domains by REPLIseq.

Each Infinium probe was annotated to late replication, intermediate replication, or early replication according to the replication timing value at each Infinium probe position (late replication, replication timing value ≤ −0.4599; intermediate replication, −0.4599 < replication timing value ≤ 0.80074; early replication, 0.80074 < replication timing value).

Methylation changes related to replication timing in IDH-mutant gliomas.

Rhind, N. & Gilbert, D. M. DNA replication timing.

Shufaro, Y. et al. Reprogramming of DNA replication timing.

On average, altered replication timing domains were ~295 kb wide.

Red and blue bars of replication timing data indicate positive (early) and negative (late) replication timing values, respectively.

We found a remarkable correlation between the borders of LADs and the transition from early replication timing outside the LAD to late replication timing within the LAD.

Therefore, fine regulation of replication timing is crucial for DNA protection.