A potential surrogate endpoint is an endpoint obtained sooner, at less cost, or less invasively than the true endpoint of interest.
It would be difficult to look back on it and imagine acting on it sooner with less information.
The same economic forces that are encouraging couples to trim their expectations may actually be encouraging more of them to marry sooner, if less expensively.
Perhaps more could have been done and sooner, and less grudgingly, but thousands of Poles from all walks of life and every political stripe aided Jews in defiance of draconian Nazi laws.
All of this will be designed to help people get a foot on the housing ladder earlier – which may lead to couples starting families sooner, meaning less demand for IVF and, perhaps, fewer stunned parents sitting on benches outside fertility clinics having just been told "expect twins".
Since the more employable workers leave unemployment on average sooner, it less likely that they enter treatment.
Rigorously designed research implemented in a cooperative and collaborative way could bring resolution to key issues much sooner (and less expensively) than if utilities continue to go it alone in testing programs.
I'm sorry we can't be together sooner, but less than two months is still right around the corner".
The program allows students to earn a degree when they show they've mastered the course content, rather than based on the number of hours spent in the classroom -- theoretically allowing them to graduate sooner for less money.
EGT's effect on speed of kill (O'Reilly and Miller 1989) makes it easy to propose an explanation for how deletion of this gene leads to reduced fitness with respect to yield: larvae die sooner and have less time to grow, and hence there are simply less host resources available for the virus to convert to transmission stages.
However, this was difficult to match with actual cases, while there could have been alternative explanations for this phenomenon, for example, that people would come and seek care sooner in a less advanced stage of the disease and hence the conditions attended would become less severe.
