Sentence examples for somewhat deleterious from inspiring English sources

Moreover, geaA1 is hypomorphic (or GeaA1 is somewhat deleterious), as geaA1 single mutants grow less than wild type.

Estimates that as many as 23% of amino acid mutations are somewhat deleterious, and present mostly in heterozygous individuals [ 35], suggests that consanguinity should increase homozygosity at these sites and lead to more pronounced effects in inbred populations.

This suggests that in both S. Typhi and S. Typhimurium, approximately half of all non-synonymous SNPs are somewhat deleterious and removed rapidly from the population via purifying selection; however after this there is very little evidence of further selection.

In other words, mutations that make the protein or the protein-ligand complex less stable than the starting point are infinitely deleterious, mutations that maintain those stabilities but enable binding of the decoy ligand are somewhat deleterious, and all other changes are neutral.

Integration was barely detectable at 16°C and was inhibited somewhat at 37°C, possibly reflecting the deleterious effect of high temperature on the oocyte.

However, analyses on sexual oDNA recombination in yeast and Chlamydomonas somewhat argue against the widespread occurrence of deleterious epistasis between oDNA alleles, since the expected segregation distortion is not normally observed (Box 4).

Here, somewhat counterintuitively, acute and chronic upregulation of PGC-1α results in deleterious cardiac phenotype [ 4, 5].

The avoidance of Muller's ratchet via transformation and recombination with eDNA might appear somewhat paradoxical because on average eDNA is expected to carry more deleterious mutations than the DNA in live prokaryotic cells.

And there's also been a heady, if somewhat contradictory, brew of studies purporting to demonstrate caffeine's beneficial and deleterious effects on humans.

Because each algorithm used a somewhat different set of criteria to predict if a SNP would be deleterious, we decided to place increasing confidence in SNPs predicted by multiple methods.

The latter two situations, though somewhat counterintuitive, may correspond to a therapy which reduces LOS but has a deleterious side effect in some patients which increases mortality.