Since then indications for adjuvant or radical treatment of non-small-cell lung cancer have changed resulting in a dramatic increase in the use of sequential and concomitant chemotherapy with radiation therapy and a more limited irradiation of the oesophagus, although with sometimes higher doses to small volume of the organ.
In the early 1900s, diabetics were sometimes given high doses of aspirin, which is an anti-inflammatory, Dr. Olefsky said.
He and others worry that while a few people may have chronic Lyme disease, thousands more are being treated for the condition with high -- sometimes dangerously high -- doses of antibiotics.
Doctors and nurses are keen to draw a distinction between palliative medicine – which is sometimes taken to mean high doses of morphine at the very end of life – and palliative care, with the psychological support it offers to the dying and their relatives, as well as pain relief.
It should be stressed that therapeutic studies on animals sometimes involve the application of high doses of anti-oxidants exceeding recommended human allowances that clinical researchers are reluctant to use in trials.
During the Chernobyl accident in Ukraine in 1986, when the reactor caught fire, operators and firefighters received high doses of radiation, sometimes within minutes and without being made aware of the dangers.
As reported by other authors, despite of being safe, high doses of antivenoms sometimes used in Brazil to treat patients with proven or suspected Bothrops/ Lachesis envenoming may contribute to early anaphylactic and late (serum sickness) type reactions [ 7].
On a purely biological level, the improvement made by D.B.S. sometimes amplified the side effects of the high doses of medication the patients had been taking.
Buprenorphine cannot be dialyzed and very high doses of naloxone are sometimes needed to reverse respiratory depression (Orwin et al 1976; Knape 1986; Gal 1989), because of the high affinity of buprenorphine to the mu receptor as well as the slow dissociation from the receptor.
In these people, high doses of primaquine given over several days sometimes destroys red blood cells, causing anaemia and, in some cases, possibly life-threatening effects.
