Sentence examples for some very significant problems from inspiring English sources

"It's unusual for an E.I.S. to indicate that even with mitigation measures, there are still going to be some very significant problems," said Eric Goldstein, a staff lawyer with the Natural Resources Defense Council.

They don't obey orders and can cause very significant problems.

"It would indicate the team cannot get loans from normal commercial sources, which could be taken as a sign of very significant problems".

No one knows exactly how higher average temperatures will translate into, say, changes in precipitation, but, considering that there are more than six billion people on the planet, it wouldn't take a very large alteration to create very significant problems.

The 111 service had "very significant problems" at Easter, Dame Barbara Hakin admitted, and there is "much more work to do" on it.

"He wanted to help people solve problems, and he saw the world as having very significant problems.

"If we can't do this little, simple thing of leading by example, then our country is doomed because that means the very significant problems in front of us we can't solve either," Coburn said Thursday in brief remarks before the vote.

Despite the very significant problems with signal-to-noise ratios that still severely limit the conclusions that can be drawn from such studies, progress has been made in identifying susceptibility loci involved in, for example, diabetes [ 161- 163], obesity [ 164], and breast or lung cancer [ 165- 167].

"There are still some very significant credit problems in the U.S. and as they pertain to commercial real estate are still extremely problematic.

NICK PAUMGARTEN: Some of the women I talked to would say this was a very significant problem.

So therein lies a very significant problem".