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Despite some unexplained heterogeneity, the timing and dose intensity of cisplatin-based neoadjuvant chemotherapy appears to have an important impact on whether or not it benefits women with locally advanced cervical cancer and warrants further exploration.
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Different definitions of weekends or nights, types of facility, or mixes of patients may explain some of the unexplained heterogeneity.
Finally, in the current analysis we could not distinguish between BHV-1 sub-types, the epidemiology of individual types might be different and this might account for some of the unexplained heterogeneity.
However, the results from meta-analyses should be interpreted with some caution as there was evidence of unexplained heterogeneity between studies.
Random effect terms were used to account for unexplained heterogeneity.
The analysis of data from populations with unexplained heterogeneity presents special challenges to researchers.
Mixture distributions provide flexibility in modeling data collected from populations having unexplained heterogeneity.
In this article, marginal means of counts with unexplained heterogeneity were modeled using two-component finite mixture distributions.
While unexplained heterogeneity is not uncommon in meta-analyses of observational studies, it means that less emphasis should be placed on the SOR.
For counts having unexplained heterogeneity, we extend the degenerate component of marginalized zero-inflated models to standard count distributions for more flexible modeling of the marginal mean.
Additionally, large unexplained heterogeneity suggests that studies may be evaluating different effects or compounding biases (Higgins et al. 2003; Higgins and Green 2011).
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