Thyroid tumours are the most prevalent endocrine malignancy and some subtypes, anaplastic and poorly differentiated carcinomas, are associated with significant morbidity and mortality (Hedinger et al, 1989).
Due to a morphological continuum between some thymoma subtypes and some morphological overlap between thymomas and TC, a variable proportion of cases may pose problems in classification, contributing to the poor interobserver reproducibility in some studies.
However, more education is needed, because many general practitioners and even neurologists at primary care and secondary care levels find the relative complexity of some headache subtypes and their diagnostic criteria confusing.
A mutation analysis may add prognostic information for GIST patients, especially for some specific subtypes, and genotyping can provide critical biomarkers to predict the activity of TKIs.
It contains annotations for diseases and normalization to UMLS unique concepts for some semantic subtypes and was used for the development of named-entity recognition tools for disease names, such as the recent DNorm system.
For example, prenatal stress in rodents leads to lateralized changes in PFC DA function [ 25, 26], alterations of PFC neuronal structure (e.g. spine density and dendritic complexity; [ 27]), and long-lasting changes in some subtypes of dopamine and glutamate receptors [ 27], which are thought to underlie cognitive and emotional deficits observed in prenatally stressed animals [ 26].
Similarly, the relationship between some subtypes of TIL and breast cancer survival is supported by some studies [ 13- 15].
However, we cannot exclude that there may be some protein modifications increasing enzymatic activity without increasing its expression, but this has never been found till now, whereas increment in some subtypes (sPLA2-IIA and -IB) has been demonstrated in adult ARDS patients [ 5, 6, 37].
Large numbers of viruses were detected during some sampling periods but not others, and some subtypes were often identified at the same time and location.
