The success of Mr. Colbert's program (its eight-week tryout was quickly extended to a year) came in a year of sizable changes in real broadcast news, most notably among the network evening newscasts.
For 9 of its 10 years, the only sizable changes the Game Boy underwent were shedding a few inches and ounces to make it easier to fit in a pocket or school bag, and losing its original drab gray finish for flashier colors like red, yellow, silver and see-through "Atomic Purple".
It's Honest and Dollar Shave Club, both pretty sizable changes to products or how they are sold, supplied and paid for.
There have been no sizable changes on that front, including user-initiated changes to privacy settings and sharing, The Wall Street Journal recently reported.
The net-net is that this provision has been particularly challenging for startups, which often trigger this limiting condition, given they frequently operate in the red through growth stages and often see frequent, sizable changes in their ownership structure due to fundraising, public offerings and acquisitions.
A regular stream of reports is coming out of Nordic and Baltic states about their efforts to modernize and expand military capacity, with countries from Sweden to Latvia making sizable changes to their militaries and arsenals in response to a heightened sense of threat from Russia.
In conclusion, log transforming the environmental factors did not lead to sizable changes in interaction OR as compared to using the non-logged factors for our top findings.
Also, these peptides were chosen for detailed analyses because in their binding of the modified hASLLys3UUU, they exhibited sizable changes in fluorescence that could be accurately quantified.
Although this limitation is inherent in the observational nature of the study, we adjusted results for known potential confounders and there were sizable changes to the risk estimates.
Nevertheless, the lack of cooperativity for E2C-18 is due to compensating changes in enthalpy and entropy and is likely associated with sizable changes in the structure of the DNA that go beyond those expected for additive binding.
