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Moreover, some evidence suggests that earlier intervention by using triptans is associated with an enhanced efficacy [11, 12], while some randomized trials do not support such an improved efficacy when patients experienced allodynia in the course of a migraine attack [13, 14].
Timing of the tracheotomy in ventilated patients has been the focus of some randomized trials [ 11].
However, some randomized trials conducted on wedged insoles have shown inconsistent results.
Some randomized trials have demonstrated that effect sizes increase when classification and matching are taken into account [ 8, 9].
Our study is a retrospective cohort study, and some randomized trials based on this subgroup of fractures should be performed.
However, celecoxib and naproxen could neither prevent AD nor improve cognitive function of AD patients in some randomized trials [ 9, 10].
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However, some other randomized trials have demonstrated clinical utility in selected patients.
9 Having examined the issues raised by the authors, what we have here is a large body of observational studies sprinkled with some prospective randomized trials that forms the basis for suggesting a paradigm shift.
There are some limitations in these studies, including the retrospective design of some studies, the use of quasi randomization methods in some of the randomized trials, the variable definition of early versus late tracheostomy, and the absence of blinding.
For the 15% estimated reduction, methodological limitations in some of the randomized trials was accounted for [ 9]; without this 'adjustment', a 20% reduction was found [ 9, 22, 52].
There is some evidence from randomized trials [ 5, 16, 17] and observational studies [ 18- 22] that surgery improves symptoms in patients with spinal stenosis.
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