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The type I thrombospondin repeats are a family of protein structural elements involved in the control of angiogenesis, and some proteins containing these repeats have been identified as negative regulators of angiogenesis.
This is in agreement with the fact that some proteins containing the BRICHOS domain were cleaved in their N-terminal part [8].
In addition, some proteins containing one of the common CCCH motifs also contained a C-X10-C-X5-C-X3-H C-X10-C-X5-C-X3-H C-X10-C-X5-C-X3-H C-X10-C-X5-C-X3-H C-X10-C-X5-C-X3-H C-X10-C-X5-C-X3-H C-X10-C-X5-C-X3-H
In mammals, some proteins containing tandem CCCH domains, such as TTP and TIS11D, have been proved to bind to the class II ARE in the 3'-untranslated region (3'-UTR) of target mRNAs and promote their deadenylation and degradation [ 71].
ORs have been suggested to be distantly related to the gustatory receptors of arthropods, with some proteins containing a signature motif in the carboxyl terminus (Scott et al., 2001).
The difference of global GC-content between the macro- and microchromosomes may potentially cause the biased distribution of gene functions between the chromosomes: some proteins containing more amino acids for GC-rich codons due to functional constraints may be more advantageous in being encoded in microchromosomes than in macrochromosomes.
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Some of the catalytic components possessed diverse hydrolytic activities ranging from exoglucanases (CelS, CbhA, CelK) to endoglucanases (CelA, CelF, CelN, CelB), xylanases (XynA/U, XynY, XynZ), and other hemicellulases (LicB, ChiA), and some proteins contained multiple catalytic modules (CelH, CelJ).
Some proteins contain as few as three amino acids, while others can contain hundreds.
Some proteins contain few linkages sensitive to tryptic digestion, and can escape identification by peptide mass mapping.
Some proteins contained domains or motifs which produced a large number of false positives, e.g. the WD40 domain of AHI1.
Some proteins contain a His-stretch with up to 29 histidines, such as Ava_3717 [Genbank:75703646] from Anabaena variabilis.
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