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Moreover, some primary studies report the statistics for the proxy variables based on different samples.
Some primary studies did not provide sufficient data or statistics to allow meta-analysis.
This problem is likely to be closely related to the problem of small sample sizes in some primary studies.
Some primary studies used different definitions of septic shock for recruiting patients, and those published before the Consensus definitions defined septic shock differently.
The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-244X/14/136/prepub wouldulikeike to thank the authors of some primary studies included in the current analysis for additional comments and data (see Table 3, 'Data location in study' column).
These systematic reviews represent the best attempts to integrate evidence of prognostic factors to date, [ 6, 8] but the findings are compromised because authors of some primary studies report adjusted estimates whilst others report unadjusted estimates and it is unclear whether the same confounders or effect modifiers have been used.
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Some of primary studies (Boylan et al., 2004, Angst et al., 2013, Grabski et al., 2008) found GAD to be the most common comorbid anxiety disorder in bipolar disorder.
There are some limitations of primary studies included that may have influenced on the results of the meta-analysis.
Secondly, authors of some of the primary studies included in this review were developing a local tool for local use and made few or no claims that their score should be generalised elsewhere.
A major concern was the poor quality of the primary studies, some of which may have been biased by company sponsorship [ 8].
Forty-seven reviews (57%) critically appraised their included primary studies using some form of checklist/assessment or described quality issues in the results or discussion.
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