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It has been shown that UCPs, by decreasing mitochondrial membrane potential, might attenuate cellular oxidative damage in some pathophysiological states leading to increased oxidative stress such as cancer cachexia [21].
Interestingly, both barriers become more permeable in some pathophysiological states, facilitating the humoral communication pathway between the brain and lungs [ 26].
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Melatonin (Mel) has been successfully used as a potent antioxidant against many pathophysiological states.
Three pathophysiological states have been described for cardiogenic shock (Fig. 1): Fig. 1 Cardiogenic shock Warner Stevenson concept (2).
Up-regulation of ligand and receptor is also associated with pathophysiological states such as cardiac dysfunction and neovascularisation.
In the following review, a description of cellular redox regulation under normal and pathophysiological states will be presented.
Recent studies also revealed the functional roles of MED12, MED13, and MED13L in cardiovascular and systemic metabolic regulation in both physiological and pathophysiological states.
The B1 receptor (B1R) plays an important role in various pathophysiological states including chronic inflammation, pain, hypotension, trauma and proliferation of cancer.
The signature of cellular mRNAs translationally stimulated by HCMV resembles pathophysiological states (such as cancer) where translation initiation factor levels or activity increase.
The structure of the synthesized inhibitors was designed to target human neutrophil elastase, a serine protease whose uncontrolled activity may lead to development of several pathophysiological states such as rheumatoid arthritis, cystic fibrosis or tumor growth and invasion.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38- or 27-amino acid neuropeptide with promising therapeutic applications for the treatment of several pathophysiological states related to neurodegenerative diseases.
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