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Honolulu, the paradise of the American imagination back in the 1960's and 70's, has slipped some notches on the average traveler's top 10 list.
But they have some notches on their belt already.
In India, Modi has generally gotten high marks for foreign policy but some notches below that for slower than expected economic reform.
Try to commit as little as possible while you get some notches under your belt.
Furthermore, in some recordings and models of the CM, some notches can be observed in tuning curves of the CM [ 212, 230].
However, in these studies, notch progression was inconsistent; some notches were stable after 1 year and others displayed progression even after 3 or 4 years.
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Some Notch target genes are also downregulated in brains and iPSC-derived cortical neurons of C9ORF72 patients.
Perhaps, some Notch target genes require co-repressors for full silencing whereas others like vg do not.
Among these, in breast cancer, medulloblastoma, multiple myeloma and mesothelioma, some Notch paralogs have an oncogenic role whereas others behave as tumour suppressors modulating differentially downstream targets.
Consistent with these findings, we found lower expression levels of some Notch target genes in iPSC-derived cortical neurons and brain tissues of C9ORF72 patients.
Additional work has shown the existence of a neutral 5 ′ -CAG expansion in some Notch alleles corresponding to the opa32 type encoding Q13HQ18 (Tautz 1989; Lyman and Young 1993).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com