Exact(3)
As a result of this, some mutations to the regulatory housekeeping gene targets of antibiotics confer both antibiotic resistance and an adaptive effect unrelated to antibiotic exposure.
Functional studies, performed for only some mutations to date, have shown that CIP-associated mutations lead to a loss of function of Nav 1.7 [ Cox et al., 2006].
Thirdly, due to the fact that mutation validation is time consuming, especially for multi-copy genes, and that the uneven pooling and PCR efficiency will all cause some mutations to be easier to detect than others, our mutation detection strategy focused on efficiency instead of detecting all possible mutations.
Similar(57)
In some proteins, mutations to such residues can radically change the primary folding route.
However, preclinical methods do not predict the resistance of some oncogenic mutations to therapy, which is later detected in many clinical studies.
However, the observation that LGI proteins multimerize (Fukata et al., 2006) suggests a potential for some LGI1 mutations to exert dominant negative effects.
However, in some viruses, mutations to the virus genome may result in proteins that are recognized to a lesser degree by the human immune system, leaving individuals susceptible to future infection.
When the mNG method is used, ω2 is slightly underestimated (fig. 3 B), likely because some synonymous mutations to ORF2 are beneficial to ORF1 and are fixed by positive selection.
This is because some synonymous mutations to one ORF are nonsynonymous to the other ORF and hence have been removed by purifying selection, causing overestimation of ω1 and ω2.
We arbitrarily count half the genes, in that we allow some "lethal" mutations to have occurred in leaf tissue, and any such cells will simply die at that point, and not affect the ongoing activity of the leaf.
HIV viruses mutate rapidly, and some mutations lead to drug resistance of current HIV treatments.
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