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The phase-I study of XL281 (NCT00451880) in an unselected patient population showed prolonged disease stabilisation in two patients with BRAFV600E mutant papillary thyroid cancer (>15 and 17 months, respectively) and some minor responses in nine patients with colorectal, ovarian and non-small-cell lung cancer.
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Some patients developed minor responses that did not classify as PR but with a definite decrease in the size of visceral lymph nodes (patient 4), subcutaneous nodules (patient 7) and cutaneous disease (patient 9).
7, 8 Phase I and II clinical trials have been conducted in patients harboring recurrent GBM where CpG-28 has been locally administered into the tumor mass; both showed a good safety profile and some cases of minor responses.
The possibility that CC-5013 may boost previously induced immunity is suggested by the fact that five patients with minor responses and static disease had previously been given some form of immunotherapy, such as melanoma peptides or IL-2.
One partial response (−78%) and 3 minor responses (−33%, −26%, and −25%) were observed.
Similar, although minor, responses were observed with 60 and 90 nM α-Hemolysin.Alteration of the epithelial parameters points to a correlation with toxin-dependent channel formation.
Only minor responses or stable disease were observed.
There were two minor responses (Cases 3 and 6).
This definition made no distinction between major and minor responses.
Two other patients had minor responses to SPI-77.
There were one complete, three partial and five minor responses, objective response rate: 9.5%.
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CEO of Professional Science Editing for Scientists @ prosciediting.com