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Paris and Ile de France Region, where our study was conducted possess an incidence rate nearly 3 times higher than our national incidence rate [9], and in several areas, close to incidence rate observed in some high burden countries described above.
Contrary to our findings, in some high burden TB settings the predominant MTB genotype has been associated with M/DR.
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However, in some high-burden countries such as in South Africa, up to 77% of recurrence is due to new infection and not relapse [ 15, 16].
Moreover, in some high-burden countries, baseline adherence rates measured using validated methods are already >97% on SAT [ 37], and there may be no room for further improvement in adherence with DOT.
Most Pacific communities have a high prevalence of non-communicable diseases, and some also have a high burden from communicable diseases such as tuberculosis and dengue fever [ 11, 12].
Some carers shoulder an overly high burden, and others become disempowered from contributing to the management of the illness.
In some Asian countries, the proportion of TB patients who seek health care in private health institutes is high [ 11]; Therefore, some high TB burden countries such as India, Nepal, Vietnam, and the Philippines have developed public-private mix cooperation mechanisms, some of which resulted in great increases in case detection [ 12, 13].
That's a high burden of proof.
They impose a high burden on under-funded health services.
And regulators face a terribly high burden of proof.
Setting: The Philippines, a high burden country for tuberculosis (TB).
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