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Some genes contributing to differential adaptation may not be detectable as peaks on such genome scans, particularly if the beneficial mutation(s) arose from standing variation and/or the effect sizes are very small; more modest changes in allele frequency may nonetheless be significant for adaptive events in natural populations (Pritchard and Di Rienzo 2010).
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In fact, it would be expected that altered expression of some genes contributes to the general drug-resistant phenotype seen in all colorectal adenocarcinomas, while expression of others distinguishes individual biologically distinct subtypes and determines their relative clinical responsiveness.
Some specific genes contributing to the development of asbestosis and asbestos-related cancer have been described, as reviewed in [ 4].
Some of the genes contributing to core enrichment of this pathway included cytochrome c oxidase subunits 6C, 7B and 7C, NADH-coenzyme Q reductase, NADH deyhdrogenase beta subcomplex 3, etc.
Examples of some of the genes contributing to the "cytoskeleton and contractile fiber" pathway are DMD, EPB41L2, MYH7, PGM5, and TRIM32, where we observed rare exonic losses in cases but not in controls.
But in their worst nightmares, they discover that the genes contributing to mental illness are so manifold, so tiny in their effects and so complex in their interplay that identifying them is a hopeless task.
Among the studied metabolites; enzymes and genes contributing in 2AP biosynthesis are highlighted in Fig. 7.
This identification of genes contributing to broad-spectrum disease resistance facilitates the introgression of donor alleles into adapted cultivars.
TaExpA6, one of the expansin genes contributing to the elongation of endosperm, seems crucial for grain growth.
We present a new multilocus method for the fine-scale mapping of genes contributing to human diseases.
The genes contributing to chronic disease are multiple, interactive, and all subject to outside influences.
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