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The LMTD methods are well established in the Chemical Engineering framework and, in general, apply a counterflow LMTD corrected by some factor to assess the "true" mean temperature difference between the fluids exchanging heat.
Some constants are often added to the this duration (a grace period) or the purchased amount has been multiplied with some factor to allow for lower adherence, as prescribed medications are often taken at a rate less than instructed [ 7].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com