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Recently Wardowski [9] was introduced the concept of set-valued contractions in cone metric spaces and established some end point and fixed point theorems for such contractions.
The time dependency is expressed in a prehormetic low-dose region of the dose response curve for some end point that is monotonic early in time, that is, is in the opposite direction of the later hormetic or "compensatory" segment of that curve (e.g., Calabrese and Baldwin 2001c).
An action spectrum shows the relative effectiveness of each wavelength (nanometers) toward some end point that can be used to weight spectral outputs of different sources like the sun or a tanning bed in order to estimate amounts produced for example, erythemal response (sunburn) or vitamin D3 production.
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For some end points the preferred methods are not clearly specified (e.g., for mutagenicity testing).
In fact, additivity on some end points plus interactive effects on others are probably more likely than either alone.
However, it appears that some end points may be adversely affected by MeHg without experiencing counterbalancing benefit from PUFAs.
For some end points, the effects of the secondary agent plus BaP are opposite to those of BaP alone.
Because the study was not a survival study some end points, including bone marrow suppression and clinical histology, were not determined.
Because multiple comparisons were involved and some end points were related, the congruence and plausibility of the results were considered in interpreting significance.
However, the results found in studies thus far suggest that endotoxin contamination may lead to overestimations of ENM toxicity for some end points.
The dose response functions described by Scholze et al. (2001) assume monotonic increasing relationships, but some end points studied here yielded monotonic decreasing forms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com