These authors found that both the clinically affected and unaffected siblings had inherited the same GNAS1 allele from their affected mother, indicating that some dissociation must have occurred between the genetic GNAS1 defect responsible for the disease and its epigenetic mark.
Reviewer #2: In general, what is missing from the paper is some element of dissociation between V1 spatial and visual responses.
That is, as we were mainly focused on characterizing whether PMC and mPFC deactivations were associated with different traits, and although the overall correlation patterns observed in Table 1 suggest some degree of functional dissociation between PMC and mPFC, we cannot infer whether, for example, the correlation coefficients for PMC/ME and mPFC/ME were different.
While some researchers found a dissociation between activity during reward anticipation in the ventral striatum and reward consumption in the ventromedial prefrontal cortex (vmPFC) including the OFC (e.g., [4], [5]), others observed that the ventral striatum was also activated during reward outcome [6] [8].
There is some evidence for a dissociation between the anti-inflammatory and antinociceptive effects, in keeping with both peripheral and central sites of action [ 24].
Third, our method cannot capture the temporal relationship between two functional networks represented in MCI 1 and 2. From a theoretical point of view, one would expect some degree of temporal dissociation between them, since the two neuronal networks are spatially segregated but probably reciprocal to each other with respect to alertness.
In addition, the discovery of C9ORF72 mutations as a cause of FTD may help to resolve some confusing dissociations between two genes that, when mutated, cause ALS but rarely FTD, yet are found at autopsy in the form of insoluble protein deposits in both disorders: TDP-43 and fused in sarcoma (FUS).
Dissociating hippocampal subregions: double dissociation between dentate gyrus and CA1.
Some recent studies propose a functional dissociation between the lateral and mesial OFC activation.
Taken together with our findings, those data corroborate the hypothesis that the PNPLA3 rs738409 may contribute to the dissociation between NAFLD and insulin resistance observed in some individuals (38).
