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Most QTLs controlling economically important traits in papaya have not yet been characterized, including those for controlling sugar content, fruit size, shape, and weight, and some complex disease reactions.
Most of these repetitive DNA sequences have some important biomedical functions and are closely related to some complex disease [ 20, 21], such as cancer [ 22], neuropsychiatric disorders [ 23], and autism [ 24].
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Some complex diseases are not caused by the maturation of single gene or single protein.
In some complex diseases, the practical feasibility of a systems medicine approach has already been proven successful [ 8– 10].
Attempts to unravel these genetic and environmental roles have met with only limited success for some complex diseases [ 6].
Drug combinatorial therapy could be more effective in treating some complex diseases than single agents due to better efficacy and reduced side effects.
A thorough analysis of virus-host interactomes may reveal insights into viral infection and pathogenic strategies and help identify novel drug targets [ 8] and decipher the molecular aetiology of some complex diseases [ 9].
At the population level, the incidence rates of some complex diseases like cancer vary between populations from different continents, probably as a result of adaptation to local selective factors but also as a result of genetic ancestry.
It is thus possible that loci contribute to some complex diseases only by their interaction with other genes, although the main effects of the individual loci may be too small to be observed (11).
Comprehensive understanding of how viruses and their host interact appears as a major milestone in the quest of deciphering viral infection processes and the molecular aetiology of some complex diseases.
Other famous TCM herbs (e.g., Ginkgo biloba, Salvia miltiorrhiza, Hypericum perforatum, and so on) are also widely used in WM for treating some complex diseases such as Alzheimer and Asthma.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com