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The weakness of our study is that despite the large overall numbers, some comparator groups still have small numbers, leading to poor precision of estimates.
South Africa's expenditure on tuberculosis (TB) research and development (R&D) is insignificant relative to both its disease burden and the expenditure of some comparator countries with a minimal TB incidence.
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The geometry of the network may show that some (head to head) comparisons have been ignored or that some comparators were preferred.
The variation in methodology for deriving clinical inputs could be explained by the lack of data for some comparators as well as by the difficulty in performing indirect comparisons due to differences in outcome measures between the trials.
Furthermore, even if separate analyses are conducted for each summary measure available, this may have undesirable consequences by: producing conflicting results; producing coherent results that would not be supported by an 'all embracing' analysis; and unlinking some comparators from the network entirely.
Both are derived relative to some relevant comparator.
93 94 95 96 Finally, studies suggest that some "active" comparators in head-to-head randomised trials are presumed by trial investigators to be effective despite having never previously been shown to be superior to placebo.
43 The review finds that dulaglutide is effective in the treatment of patients with type 2 diabetes mellitus, and may have advantages, such as in weight change, over some active comparators.
However, the curvilinear relationship between ADMINCOST and DOSFREQ raises an interesting scenario that, given the peculiar biophysical characteristics and pharmacokinetic profiles of a biologic drug candidate, it is possible to have lower ADMINCOST when DOSFREQ is higher relative to some appropriately defined comparator drug.
It is possible that many respondents may have initially applied an unwritten qualifying context for the anchors, such as best or worst health 'that is possible for me,'thatat I have experienced,'foror my age', or some other social comparator.
Some have no comparators (C), some have brownout reset (BOR), and the ADC varies from slope to SARs.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com