Our findings could be valuable for designing alternative therapies to alleviate the clinical manifestation of the cblC disorder, as some of the protein changes detected in our study are common hallmarks of known pathologies such as Alzheimer's and Parkinson's diseases as well as muscular dystrophies.
Invasion and metastasis is one of the most common hallmarks of cancer, especially those with high grade malignancy.
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types.
Aberrant DNA methylation and chromatin modifications, altering gene transcription states, are common hallmarks of human tumour cells [ 24].
Alongside known genetic changes, aberrant epigenetic alterations have emerged as common hallmarks of many cancers, including glioblastoma.
Despite the different histopathologically characterized lesions of MS, they share common hallmarks that include areas of focal demyelination with inflammatory infiltrating immune cells, along with axonal injury.
Morphological abnormalities in dendritic arbourization and postsynaptic structure are common hallmarks of a number of cognitive diseases, for example, mental retardation (Bagni and Greenough, 2005).
Previously, it has also been demonstrated that genetic defects in miRNAs, their processing machinery and epigenetic regulations are common hallmarks of human diseases [ 3].
Membrane trafficking is critical for cell survival and defects in transport to the membrane are common hallmarks of neurodegenerative diseases, including FTLD [ 35].
Common hallmarks of neurodegeneration, including accumulation of ubiquitinated proteins and α-synuclein deposits found in PD, are also seen here in GD mouse brains.
