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Without head to head competition in the market place (akin to the generic substitution that we see today for traditional drugs) the cost to the consumer may not come down, and some biologics may have indefinite monopolies.
Meanwhile, recently developed T-cell based procedures are showing promise for predicting potential immunogenicity with some biologics including monoclonal antibodies.
In addition, some biologics, such as infliximab, are dosed intravenously, which can be inconvenient for patients.
ATA status was selected because it has been shown to have an effect on the pharmacokinetics for some biologics.
These data strongly argue for a clear-cut need for biomarkers capable of identifying, at baseline, which RA patients having different pathways will be the best responders to some biologics or poor responders to other biologics.
For example, our classification of treatment as biologic, hormone, or chemotherapy was performed a priori, with input from oncologists and pharmacologists; however, some biologics may be classified differently by others.
Similar(50)
But elsewhere in science, cloning refers to outcome rather than process: it denotes replication of some biologic entity -- perhaps an organism, but perhaps only one cell, or perhaps just a stretch of DNA.
Our results suggest that this is possible but then the curvilinear relationship between ADMINCOST and DOSFREQ means it is also possible for some biologic drugs (given their peculiar biophysical characteristics and pharmacokinetic profiles) to have lower administration costs even with a higher annual dosing frequency (relative to some other biologic drug).
Despite early belief that the fully human nature of these proteins would represent a significant advantage, adverse effects associated with immune responses to some biologic therapies have become a topic of some concern.
However, there is some biologic plausibility to considering a link between stress and reproduction.
While it is possible this is only secondary to platelet activation, there may be some biologic importance to its elevation during sepsis given the demonstrated effect on phagocytic function in the current report.
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